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Structural framework for covalent inhibition of Clostridium botulinum neurotoxin A by targeting Cys165.

Clostridium botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins for humans and a major biothreat agent. Despite intense chemical efforts over the past 10 years to develop inhibitors of its catalytic domain (catBoNT/A), highly potent and selective inhibitors are still lacking. Recently, small inhibitors were reported to covalently modify catBoNT/A by targeting Cys(165), a residue located in the enzyme active site just above the catalytic zinc ion.

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Understanding new laws of physics

Stimulated by the race towards miniaturization in the microelectronics industry, research in Nanosciences is conducted at two departments within the Physical Sciences Division: Iramis in Saclay and the Inac in Grenoble.

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InVivo imaging platform
Life Sciences Division

In-vivo imaging platforms in the Paris Region. Along with other research agencies, the Life sciences division is complementing the technical resources located in the Paris area (and including the imaging facilities of the Service Hospitalier Frédéric Joliot in Orsay) with two new imaging platforms, thus taking an active part in the formation of an European centre of excellence....

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International Office
Discovering the International Office website

Coming to work at CEA Saclay? Find all useful information to prepare your stay on the International Office website!

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